I may surprise people with this sort of non-curmudgeonly take....haha.
The tournament committee generally does a pretty darn good job in selecting the field and the seeding. Although the NET ratings and the Quads are not perfect - think they're more representative of the objective criteria you'd want over our former tired old friend, the RPI. Also, expanding to 68 and the pod-system has evened things out more so geographically, so there's less of a tendency for one of the top-16 seeds to get a raw deal, so-to-speak.
Now, I do think it would be interesting to go back to the fixed bracket (w/o pods), and see how the top seeds perform, or if you reversed some of the rules for teams in the same conference.
'84 and '86 - yeah, Purdue got no favorable treatment playing Memphis and LSU on their respective home courts. Then, they really got dinged in '87 for one really bad (well, terrible) game to end the regular season. Now, to be fair - Purdue's last National Semi-Finals appearance - 6th-seeded Boilers played the first two rounds in Mackey Arena, IIRC. That Mideast Region was all set up for Kentucky/Indiana in Rupp Arena, but Duke and Purdue did not get the memo.
Now.....you still don't know the rest of the story......good day!