If Brohm uses Moore as the Swiss army knife yardage monster that he was his FR year, he's got a puncher's chance to make a run at the Heisman in the Reggie Bush mold. He'd need more rushing attempts/yards, but he could do it.
As Pu71indy said, a lot of that will depend on how the other receivers change the offensive ball distribution. It could be more evenly split because of guys like Bell, or it could end up with a lot more 1-on-1 on Moore and lets him tear it up.
Best case scenario for Moore is probably like, what, 1,400 receiving, 400 rushing, and 20 TDs.
The biggest obstacle is going to be PU's win total, even bigger than position bias. Those kind of numbers on a 10-win team would have him in the national conversation. A 5 or 6 win team? Not so much. I could see PU very plausibly being in either of those win-total situations. Your team is going to need to come out of the gate a lot hotter than the last two years, but it's certainly possible to be one of those special years.