FDB,
Higher ("protected") seeds are supposed to be also "not at a geographical disadvantage." Not sure if this really would be one as Lexington isn't that much further, but I think if it's more than 100 miles, I guess it could be. Even with that, Lunardi's bracket routinely doesn't follow all the committee protocol. For instance, sometimes he'll have conference foes scheduled to potentially meet before the regional final when they could be in another bracket or at least different side of the same bracket.
To close the loop on Kentucky.....in reality, they are almost never at a disadvantage.....at least from the crowd perspective......they pack just about every regional site like crazy. Some interesting headware and face painters as well.